Epitope/Antigen: Factor XIIIa C-terminus Total Protein Concentration: ~10 mg/ml. Call for lot specific Ig concentration. Cellular Localization: Cytoplasmic Positive Control: Dermatofibroma, placenta or skin Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues) Supplied As: Buffer with protein carrier and preservative

Factor XIIIa is a pan-histiocytic marker, similar to CD68.

CD34 and factor XIIIa-positive microvascular dendritic cells and the family of fibrohistiocytic mesenchymal tumors. Plasmacytoid dendritic cells, Factor XIIIa-positive dermal dendrocytes, macrophages and inducible nitric oxide synthase expression in American tegumentary leishmaniasis skin lesions Factor XIIIa Positive Control Slides , Product No. 251S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Other Notes For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com Epitope/Antigen: Factor XIIIa C-terminus Total Protein Concentration: ~10 mg/ml. Call for lot specific Ig concentration. Cellular Localization: Cytoplasmic Positive Control: Dermatofibroma, placenta or skin Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded tissues) Supplied As: Buffer with protein carrier and preservative ical aid to the diagnosis of the most frequent type of EDS. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable. The biologic significance of this finding is unknown.

CD68 may highlight histiocytic cells (Patterson: Weedon's Skin Pathology, 5th Edition, 2020) FXIIIa positive cells in human skin represent a specific population of bone-marrow dermal dendritic cells, distinct from Langerhans cells, that share some features common to mononuc-lear phagocytes (monocyte/macrophages). In addition, the detection of HLA-DQ on 48"n of To assess the use of anti-CD34 and anti-factor-XIIIa antibodies for the differential diagnosis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP), we stained 40 DFs and 13 DFSPs. A significant population of dendritic and spindle cells was reactive with anti-factor-XIIIa in 90% of DFs. In DFSP, most cases had very few or no reactive tostatin-positive cells are speci¢cally involved in the healing process of psoriasis. The reduction of the factor XIIIa-posi-tive cells was associated with the healing process as a whole, but showed no relation to either treatment.Key words: dendri-tic cells; epidermal thickness; immunohistochemistry; psoriasis. (Accepted June 29, 1998.) Interaction of Human Papillomavirus DNA with Factor XIIIa-positive Dermal Dendrocytes in Vulvar Lesions Naiura Vieira Pereira 1,2 , Carla Pagliari 1,2* , Elaine R. Fernandes 1 , Fernanda Guedes 1 , Mírian N. Sotto 2 and Maria Irma Seixas Duarte 1 PDF | Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells.

Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (90% positive) and desmoplastic malignant melanoma (negative). Factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor , and meningioma.

Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency.

Keloid similarly contained trapped FXIIIa+ cells (mean score = 0.44 or < 5% positive) that were distinct from the spindle-shaped fibroblasts of the tumor mass. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm.

8 Jan 2010 the skin may reveal dual population of CD34 and factor XIIIa positive cells.6. In one study, 95% dermatofibromas revealed factor XIIIa positivity,.

Mirian Nacagami Sotto. mnsotto@ajato.com.br . SOTTO, Mirian Nacagami - Dendrócitos dérmicos fator XIIIa positivos na resposta tecidual cutânea da … Comparison of Angiomyofibroblastoma and Aggressive Angiomyxoma in Both Sexes: Four Cases Composed of Bimodal CD34 and Factor XIIIa Positive Dendritic Cell Subsets. Author links open overlay panel Jeffrey S. Silverman 1 2 Jak Albukerk 1 2 Ali Tamsen 1 2. Show more.

Clotting Factors. Factor I. Factor II. Factor V . Factor VII. Factor VIII. Factor IX. Factor X. Factor XI. Factor XIII. Factor XIII (FXIII), or fibrin stabilizing factor, deficiency was first reported in the literature in 1960. It is the rarest factor deficiency, occurring in 1 per 5 million births. 10 Apr 2018 Learn in-depth information on Factor XII Deficiency, its causes, symptoms, factors I to XIII (factors V and VI actually denote the same clotting factor) Anti- coagulant positive lupus, in which antibodies to factor With more than 17000 members from nearly 100 countries, ASH is the world's largest professional society helping hematologists conquer blood diseases The increased prothrombin protein level leads to a hypercoagulable state, i.e., an increased tendency to form blood clots.
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However, at least a subset of dermal Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages Factor XIIIa-positive cells were most numerous in the dermis and connective tissues.

1999-10-18 Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot.
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Dendritic, factor XIIIa positive cells were observed in all tissues studied, but were most numerous in skin and mucosal tissues (gastrointestinal tract, bladder). They were also observed associated with epithelial structures in lung and kidney, but were only rarely observed in liver, thyroid, testis and spleen.

We have also evaluated neurofilament in a number of these types of cases, and I have observed neu- DF stains positively for Factor XIIIa and negative for CD34, while DFSP stains oppositely with positive CD34 staining and negative Factor XIIIa staining. This differentiation is, however, not absolute, as there are reports of Factor XIIIa positive DFSPs and of CD34 positive DFs. Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot.

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Factor XIIIa (reportedly positive in neurofibroma but negative in schwannoma), and CD56 (reportedly nega-tive in neurofibroma and positive in schwannoma, although I have seen focal CD56 in a plexiform neurofi-broma). We have also evaluated neurofilament in a number of these types of cases, and I have observed neu-